According to Translational Psychiatry, advanced aging and premature morbidity and mortality are associated with chronic psychological stress.
Klotho is a pleiotropic hormone and serves the following functions:
• Regulates the aging process;
• Promotes better brain and body health;
• Regulates insulin Wnt and N-methyl-D-aspartate receptor signaling;
• Influences ion channel clustering and calcium homeostasis
• Promotes FGF23 activation;
• Provides protection against endothelial dysfunction;
• Suppresses oxidative damage and
• Aids in regulating inflammatory activity.
Comparably, both klotho’s and psychological stress’ negative impact on humans is unknown.
To address the unidentified impact, 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder or low-stress control mothers of a typically developing child were recruited for procedures.
Results showed participants under high chronic stress with more depressive symptoms displayed significantly lower levels of the klotho hormone in comparison with low-stressed participants. The decrease among those under high stress was age-dependent.
This outcome provided the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting:
• Depression and
• Risk for accelerated disease development.
Furthermore, these findings have important implications for understanding the aging process and may represent a therapeutic treatment for the dangerous effects of chronic psychological stress on health and well-being.