On Apr 1, 2026 Givaudan Active Beauty announced the debut of the PrimalHyal 300, its new hyaluronic acid serum for fast skin recovery and repair .
Derived from biotechnology, the medium molecular weight hyaluronic acid acts strengthens the skin’s natural defense system and helps accelerate recovery when the barrier is compromised, particularly in post-procedure care.
“Our skin is our first line of defense — a complex and dynamic structure that must repair itself effectively when compromised,” notes Amandine Scandolera, Head of Biological Evaluation at Givaudan Active Beauty. “PrimalHyal 300 is the result of years of research into how hyaluronic acid can support the skin’s natural repair and cell reconnection processes. By specifically reactivating bleomycin hydrolase production, it helps the skin heal better, faster and more effectively.”
Related: Givaudan Active Beauty Launches PrimalHyal NeuroYouth to Target Skin Ageing
With aesthetic treatments having increased fivefold over the last 30 years, understanding and supporting this mechanism has never been more critical. Recent scientific discoveries have highlighted bleomycin hydrolase as a key enzyme involved in hydration, wound healing and epidermal barrier integrity. When the skin barrier is disrupted, fast and coordinated repair becomes essential.
PrimalHyal 300 activates skin renewal by boosting bleomycin hydrolase levels by 79%, helping the skin remain hydrated while accelerating its natural recovery.
These effects were confirmed by clinical studies conducted on women who underwent deep fractional CO2 laser treatments:
- After three days: visible improvement in hydration
- After one week: substantial reduction in redness and irritation
- Overall: smoother, calmer and more resilient skin
“Our skin is our first line of defense — a complex and dynamic structure that must repair itself effectively when compromised,” notes Amandine Scandolera, Head of Biological Evaluation at Givaudan Active Beauty. “PrimalHyal 300 is the result of years of research into how hyaluronic acid can support the skin’s natural repair and cell reconnection processes. By specifically reactivating bleomycin hydrolase production, it helps the skin heal better, faster and more effectively.”
As aesthetic treatments continue to rise in popularity, PrimalHyal 300 represents a science-backed breakthrough in skin regeneration, offering a new era in skin hydration, accelerated recovery and skin barrier restoration.
