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New Study Points to Six Melanoma Risk Factors

Posted: March 23, 2009

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The six factors Dr. Rigel identified, which include some melanoma risk factors that have been previously identified, are as follows:

  • History of blistering sunburns as a teenager,
  • Red or blonde hair,
  • Marked freckling of the upper back, a sign of excessive sun exposure and that a person is susceptible to it,
  • Family history of melanoma,
  • History of actinic keratoses, considered the earliest stage in the development of skin cancer, and
  • Outdoor summer jobs for three or more years as a teenager.

“When conducting this study, we looked at 43 different factors and these six factors independently predicted melanoma risk,” said Dr. Rigel. “In the average U.S. population, the lifetime melanoma risk is about 1.5% for an invasive melanoma and about 3% for all types when you include in situ melanomas. So if you have any one of these six factors, your melanoma risk goes up to about a twofold to threefold increase over the general population, or roughly a 3–5% lifetime risk of developing melanoma with any one of those factors.”

Dr. Rigel added that for individuals with two or more of these factors, the risk goes up to a five to 10 times increased lifetime risk of melanoma over the general population. In addition, those with any three or more of these six factors have up to a 10 to 20 times increased risk of developing melanoma.

Other previous studies examining risk factors for melanoma have shown correlations between melanoma and a range of associations, from certain types of cancers to socioeconomic class. Examples of these previous studies include:

  • Women and men with a prior history of breast cancer have a twofold to threefold risk of developing melanoma.
  • Women with a prior history of thyroid cancer have a twofold risk of developing melanoma.
  • A higher socioeconomic class has been linked to a higher incidence of melanoma, which Dr. Rigel attributes to this group being able to afford more vacations and leisure time that could result in more sun exposure.
  • Airline flight personnel had a higher rate of melanoma when the incidence of melanoma was examined by occupation.
  • Male drivers have been found to have a higher incidence of skin cancers on the left side of the body compared to right side of the body.
  • Taller men were found to have a higher incidence of melanoma than shorter men, with men in the top quartile of height twice as likely to develop melanoma as men in the bottom quartiles of height.
  • Use of tanning beds is a major risk factor for melanoma, with studies showing people who use tanning beds have a higher melanoma risk, a higher incidence of getting a second melanoma, and are younger when they develop melanoma.
  • Patients with a history of dysplastic nevi, or non-cancerous moles that share some of the features of melanoma, and a family history of melanoma have a 50% greater risk of developing melanoma.

“Dermatologists continually look for clues as to who is most likely to develop melanoma, and this ongoing research will likely help more people understand their own risk factors and may convince them to get regular skin cancer screenings,” said Dr. Rigel. “Unfortunately, we expect skin cancer rates to continue to climb. But, identifying additional risk factors for melanoma could lead to the early detection and successful treatment of this potential killer.”