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Inflammaging: Changing the Face of Skin Care

By: Noureddine Mriouah
Posted: January 2, 2013, from the January 2013 issue of Skin Inc. magazine.

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Of course, no discussion of inflammaging would be complete without addressing skin care’s anti-aging hero: retinol. The gold standard in renewal, retinol achieves its goal often at the cost of irritating the skin. Although retinoids themselves aren’t likely to change, science has found new ways to deliver these key ingredients through encapsulated systems that bypass their inflammatory side effects.

Inflammaging and the future of skin care

In an industry that moves at breakneck speed, the advent of inflammaging serves as both a wake-up call and an ultimatum to product developers, cosmetic companies and skin care professionals alike. The skin care game is changing, and if companies don’t keep up, their clients will look elsewhere. As science continues to explore the dynamics of inflammaging, new products and treatments will emerge to address this nascent concern.

REFERENCES

  1. G Makoto, Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?, Biosci Trends 2 6 218–30 (Dec 2008)
  2. C Franceschi, et al., Inflamm-aging. An evolutionary perspective on immunosenescence, Ann NY Acad Sci 908 244–54 (Jun 2000)
  3. C Franceschi and M Bonafé, Centenarians as a model for healthy aging, Biochem Soc Trans 31 457–461 (Apr 2003)
  4. A Salminen, et al., Inflammaging: disturbed interplay between autophagy and inflammasomes Aging 4 3 166–175 (Mar 2012)
  5. PM Elias and KR Feingold, Lipids and the epidermal water barrier: metabolism, regulation, and pathophysiology, Semin Dermatol 11 176–182 (Jun 1992)
  6. PM Elias and KR Feingold, Does the tail wag the dog: Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications, Arch Dermatol 137 8 1079–1081 (Aug 2001)
  7. S Giunta, Is inflammaging an auto[innate]immunity subclinical syndrome?, Immun Ageing 16 3 12 (Dec 2006)
  8. WP Smith, Comparative effectiveness of alpha-hydroxy acids on skin properties, Int J Cosmet Sci 18 2 75–83. (Apr 1996)
  9. KS Park, et al., Effect of glycolic acid on UVB-induced skin damage and inflammation in guinea pigs, Skin Pharmacol Appl Skin Physiol 15 4 236–45 (Jul/Aug 2002)
  10. RD Wilkinson, et al., Benzoyl peroxide and sulfur: Foundation for acne management, Can Med Assoc J 2 95 1 28–29. (Jul 1966)
  11. SH Ibbotson, et al., Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells, J Invest Dermatol 110 1 79–83. (Jan 1998)

Noureddine Mriouah is the product development director and principal scientist for CosMedix and Results Rx. With extensive training and education, including a masters of chemical engineering from the University of Paris, Mriouah is a recognized leader and expert in product formulation, research and development, production, process engineering and GMP regulations. He can be contacted at 678-303-1850 or nmriouah@astralbrands.com.

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