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Chronic Skin Condition May Lead to Tumor Growth

Posted: July 9, 2009

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The researchers also plan to use Notch-deficient mice to provide a system in which to identify molecules and cellular interactions responsible for the oncogenic effect of chronic wounds. Based on such analyses, new drug targets might be identified to develop therapies for cancers of the skin and perhaps other organs.

"It's very reasonable to assume that chronic wounds in a variety of tissues have similar characteristics," Kopan says. "The skin of these mice is easy to monitor and will give us the ability to further analyze tumor promotion and find answers that might apply to any chronic wound."

Funding from the National Institute of General Medical Sciences supported this research.

Journal reference: Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell, July 7, 2009.

Adapted from materials provided by Washington University School of Medicine.