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Drug Shows Success Healing Scars

Posted: April 20, 2009

Potentially helpful in medical spa treatments and procedures, a new drug has proven effective in the healing of scars.

The drug avotermin, which has a brand name of Juvista, seems to improve the healing of skin scars, according to three new studies.

Some volunteers had avotermin (Human Recombinant TGFa3) administered to their skin before wounding and again 24 hours later to both sides of one-centimeter incisions that went all the way through the skin of the upper inner arm to the depth of the underlying muscle. Identical wounds were inflicted on other volunteers who received a placebo or standard wound care.

Two studies found that patients who received avotermin scored an average of five points higher on a visual 100-point scale of scar appearance after six months, and an average of eight points higher after one year.

The third study found that all concentrations of avotermin produced significantly improved total scar appearance scores versus placebo*mdash;from 15 points at the five nanogram dose up to 64 points at the 500 nanogram dose. The researcher said 60% of scars treated with avotermin showed 25% or less abnormal orientation of the collagen fibers in the skin, compared with 33% of scars treated with placebo.