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Genetic Mutation Shown to Trigger Skin Cancer

Potentially helping to create new treatments for melanoma, British researchers have shown a genetic mutation often leads to the development of the disease.

Up to 70% of melanoma skin cancers may be triggered by a gene mutation that causes cells to become cancerous after excessive exposure to the sun, researchers said recently. The discovery could lead to better treatments for the most deadly form of skin cancer after scientists at Britain's Institute of Cancer Research established the BRAF gene mutation is often the first event in the cascade of genetic changes leading to melanoma.

Scientists already knew the BRAF gene was frequently damaged in patients with melanoma, but it was unclear if this was a cause or effect of the cancer.

The British institute published its findings in the journal Cancer Cell. "Our study shows that the genetic damage of BRAF is the first step in skin cancer development," said lead author Richard Marais. "Understanding this process will help us develop more effective treatments for the disease." The hope is that knowing the genetics behind skin cancer will lead to the development of targeted drugs that can fix the faulty genetic machinery.

While melanoma accounts for only a small percentage of skin cancers, it is responsible for most skin cancer deaths. The disease is characterized by the uncontrolled proliferation of pigment-producing skin cells called melanocytes.

Overexposure to sunlight is to blame for at least two-thirds of cases as DNA in sunburnt skin cells becomes damaged, leading to the genetic mutations.

Reuters, April 6, 2009

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