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New Research Shows How Oral Supplements Can Affect Skin

Posted: December 17, 2008

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The researchers, led by Alexander Schauss from the American Institute for Biosocial and Medical Research in Washington, in collaboration with scientists from Hungary's Fodor Jozsef National Center of Health, FenChem Biotek, and Salt Lake City-based Schiff Nutrition Group, used radioactively-labelled HA and fed a single dose to rats and beagles. Radioactive technetium was used to label the HA, while radioactive technetium pertechnetate was used as the control.

Ingestion of the HA by the rats showed that 87-96% of the radioactivity was recovered, with the majority in the faeces. All of the tissues studied did show incorporation the radioactive HA. Incorporation was observed 15 minutes after ingestion, and persisted for 48 hours, added the researchers. Moreover, after 24 hours, skin, bone and joint tissues all showed an incorporation of the radioactive HA. However, no radioactivity was detected in the skin, bone and joint tissues of the animals when radioactive technetium pertechnetate was used.

“HA is known to have an affinity for connective tissues, and these tissues exhibited accumulation of radioactivity throughout the study period from [radioactively-labelled HA], but not after [radioactive technetium pertechnetate],” wrote the researchers. “Overall, the findings suggest that a small amount of orally administered HA was absorbed into systemic circulation and taken up by connective tissues.”

Take-home message

“These findings support reports of biological actions seen after oral administration of high-molecular-weight HA in animal and human studies,” wrote the researchers. “Thus, a rationale for inclusion of HA in dietary supplement products designed for joint and skin health exists,” they concluded.