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Lipid-signaling Molecule May Have Anti-aging Effects

Posted: August 14, 2008

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Topical application

The team then went on to look at the effect of topically applying the activator to aged mouse skin. K6PC-5 was applied as part of a 1% solution daily for two weeks to a group of 56 week-old mice. The number of dermal fibroblasts and collagen production in the mouse skin was then compared to mice who had received the vehicle solution and those who had received nothing.

The topical application of K6PC-5 was seen to increase the number of dermal fibroblasts and up collagen synthesis, according to the study. In addition, studies were performed on the effects of the activator on the skin’s barrier function in order to determine whether the treatment could have potential negative side effects. Applying the sphingosine kinase activator to mouse skin did not alter the transepidermal water loss, skin hydration or skin pH, reported the scientists, concluding that this suggests there will be few side effects of the treatment.

The team has also reported the benefits of topical application of K6PC-5 when applied to wrinkles around the eye area via is effect on S1P, and here conclude a ‘role for S1P on the treatment of the effects of skin aging’.

Reference: Jong-Kyung Youm, Hae Jo, Jeong Hee Hong, Dong Min Shin, Mi Jung Kwon, Se Kyoo Jeong, Byeong Deog Park, Eung Ho Choi, Seun Hun Lee, “K6Pc-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling,” Journal of Dermatological Science, Issue 51, Pages 89–102, 2008