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A New Look at Cellulite, Part 1

By: Peter T. Pugliese, MD
Posted: June 26, 2008, from the July 2008 issue of Skin Inc. magazine.

page 4 of 6

1. LH initiates a biochemical pathway that stimulates the production of progesterone, cytokines and prostaglandins.

2. These biochemical agents act on granulosa cells and theca cells to produce MMPs and TIMPs.

3. The MMPs destroy the follicle permitting the egg to be released.

4. The TIMPs may orchestrate the formation of the corpus luteum by controlling cellular proliferation and steroidogenesis.

There are many steps and a great deal of information, but for the purpose of this article, this is all you need to remember.