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Research Reveals Effective Anti-aging Treatments for Skin

Posted: June 13, 2008

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The U-M researchers base their conclusions on past studies in which they have explored why certain anti-aging treatments are effective. A 2007 study looked at Restylane, marketed as a dermal filler, and found that injections of the product caused fibroblasts to stretch, promoting new collagen, and also limited the breakdown of collagen.

In another 2007 study, the U-M team tested lotions containing retinol, a form of vitamin A found in many skin care products, and found it significantly reduced wrinkles and skin roughness in elderly skin by promoting new collagen.

Other U-M studies have shown why some laser treatments work and some less powerful ones do not. Carbon dioxide laser resurfacing is effective because it removes the aging dermis; in the three-week regrowth process, new, young collagen is produced.

Voorhees and his colleagues say they provide needed, independent research on the effectiveness of available and future treatments to counteract skin aging. They have no ties to the manufacturers of products they study. Funding has come from the National Institutes of Health and U-M.

Journal reference: Gary J. Fisher, PhD; James Varani, PhD; John J. Voorhees, MD. Looking Older: Fibroblast Collapse and Therapeutic Implications. Archives of Dermatology, Vol. 144 (No. 5), May 2008