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Parabens: Paradox or Paranoia

By Peter T. Pugliese, MD
Posted: April 10, 2008, from the January 2008 issue of Skin Inc. magazine.

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       Phytoestrogens are substances from plants that have estrogen-like qualities. Soybeans, clover and strawberries all contain phytoestrogens. It is rare to read about these items when parabens are discussed, yet they are considerably more potent than parabens in terms of estrogenic effect. Most scientific opinions about phytoestrogens are favorable since substantial research indicates that they have great potential for health benefits. Asian diets, which are much higher in phytoestrogens than Western diets, seem to be associated with a lower risk of breast, prostate and colon cancers, and a reduced incidence of heart disease and osteoporosis. These findings suggest that there may be some benefits to the intake of weak estrogenic substances. The lesson here is that you must look well into a subject that has a significant effect on  health before making a decision as to whether something is beneficial or harmful.

Conclusions
       At the present time, the scientific pundits find no evidence to support the claim that parabens in cosmetics—at the approved use level—cause cancer. Not a shred of evidence exists to link parabens as a cause of cancer. No studies have been presented to show that normal use of cosmetics containing parabens is harmful. More than 10,000 cosmetic products contain parabens and millions of people use these products every day. Considering this, a significant increase in many types of cancer should have occurred during the past 20 years, when, in fact, the incidence rates of several cancers have decreased, including those of the breast, stomach, lung, colon, rectum and cervix. 
 
FOOTNOTES
a. Esters are compounds that result from combining an acid and an alcohol.
b. "Para" is a term applied to a benzene ring when one group is attached to the No. 1 carbon and a second group is attached to the No. 4 carbon.
c. NOEL is the highest dose at which no adverse effects were noted in test animals.
d. This test measures the increase in the weight of the uterus when exposed to estrogen-like material. Rats are usually used in this assay.

REFERENCES
1.  PD Darbre, Aljarrah, R Miller, NG Goldham, MJ Sauer and GS Pope, Concentrations of parabens in human breast tumours. J Appl Toxicol (24), 5–13 (2004)
2.  The European Food Safety Authority, Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission Related to Para-hydroxybenzoates E 214–219 (13 July 2004)
3.  EJ Routledge, J Parker, J Odum et al, Some alkyl hydroxyl benzoate preservatives (parabens) are estrogenic. Toxicol Appl Pharmacol (153) 12–9 (1998)
4.  T Okubo, Y Yokoyama, K Kano and I Kano, ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER? and PR. Fd Chem Toxicol (39) 12251232 (2001)
5.  RM Blair, H Fang, WS Branham, BS Hass, SL Dial, CL Moland, W Tong, L Shi, R Perkins and DM Sheehan,
The oestrogen receptor relative binding of 188 natural and xenochemicals: Structural diversity of ligands. Toxicol Sci (54) 138–153 (2000)
6.  European Commission Health & Consumer Protection Directorate, General Directorate C, Public Health and Risk Assessment C7, Risk assessment SCCP/0873/05
7.  Department Tox and Risk Assessment, Institute of Food and Veterinary Research (Sept 2004) JCL
8.  JS Fisher, KJ Turner, D Brown and RM Sharpe, Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood. Environ Health Perspect 107(5) 397–405 (1999 May)
9.  KS Kang, JH Che, DY Ryu, TW Kim, GX Li and YS Lee, Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butylparaben). J Vet Med Sci 64(3) 227–235 (2002)
10. BL Song, HY Li and DR Peng, In vitro spermicidal activity of parabens against human spermatozoa. Contraception 39(3), 331–335 (1989)
11. S Oishi, Effects of butylparaben on the male reproductive system in mice. Arch Toxicol (76) 423–429 (2002)
12. S Oishi, Effects of propylparaben on the male reproductive system. Fd Chem Toxicol (40) 1807–1813 (2002)
13. S Oishi, Lack of spermatotoxic effects of methyl and ethyl esters of p-hydroxybenzoic acid in rats. Fd Chem Toxicol (2004)
14. Parabens, FDA/Center for Food Safety & Applied Nutrition, hypertext updated March 24, 2006
15. KG McGrath, An earlier age of breast cancer diagnosis related to more frequent use of antiperspirants/deodorants and underarm shaving. European Journal of Cancer Prevention (12) 479–485 (2003)
16. DK Mirick, S Davis and DB Thomas, Antiperspirant Use and the Risk of Breast Cancer. Journal of the National Cancer Institute (94) 1578–1580 (2002)
17. National Cancer Institute, Antiperspirants/Deodorants and Breast Cancer: Questions and Answers (October 2004): www.cancer.gov/cancertopics/factsheet/Risk/AP-Deo (Accessed Jan 30, 2006)
18. CI Perkins, J Hotes, BA Kohler and Howe HL, Association between breast cancer laterality and tumor location, United States, 1994–1998. Cancer Causes Control (15) 637–6445 (2004)