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Ingredient Hysteria and Misconceptions

By: Carol and Rob Trow
Posted: January 2, 2014, from the January 2014 issue of Skin Inc. magazine.
Ingredient Hysteria and Misconceptions

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Some websites, blogs and brands indicate that vitamin A is a known human reproductive toxicant. Yet, much research shows that vitamin A is safe for use in cosmetics. In fact, vitamin A is alleged to be one of the most effective—if not the most effective—ingredient in anti-aging skin care.1 Like anything else, if you go to extremes and submerge the body in high doses of retinoic acid thousands of times the amount used in skin care products, it will harm you. But, is that reasonable? There is no proof, despite rumors and assertions, that the levels of vitamin A in cosmetics cause cancer or organ toxicity.

Propylene glycol. A much-maligned ingredient, propylene glycol is safe for use in cosmetics.6, 7 According to the U.S. Food and Drug Administration’s (FDA) Cosmetic Ingredient Review’s (CIR) National Toxicology Program, there is negligible, if any, concern related to its use. In fact, it is safe to eat. This ingredient comes in two forms: vegetable sources and synthetic sources, such as petroleum. It is safe in cosmetic use and no toxicity was found at dose levels used in skin care. The concentration in cosmetic preparations is normally under 2%. The CIR stated it is safe in concentrations up to 50%.7 There is no scientific evidence or truth to the assertions that, in the form and dose used in skin care, it causes cancer, or brain, kidney or liver damage. There are no histological refereed studies that prove the rumor that, in concentrations used in skin care, propylene glycol removes the acid mantle of the skin.

Parabens. One of the most controversial and researched preservatives are parabens. Health concerns include links to the development of breast cancer and reproductive toxicity, as well as immunotoxicity and neurotoxicity. Many are surprised to learn that parabens are nature’s way of providing self-preservation for many naturally occurring fruits and vegetables, including blueberries, strawberries and carrots. Parabens have been deemed safe, after multiple studies by the FDA, the Japanese Ministry of Health and the European Commission. Published in the International Journal of Toxicity in 2008, the CIR reported on more than 65 studies by independent scientific researchers, documenting that exposure to 840 times the amount of parabens found in cosmetics caused no adverse effects. Further, parabens do not accumulate in the body and, if there are any excess parabens, they are easily eliminated from the body.

Parabens have been the subject of much misinformation, rumor-mongering and unfounded hype about their dangers based on a few poorly designed studies.8 The FDA reviewed 110 studies and confirmed that there is no basis for concern.9–11 Lastly, in order to claim an estrogenic effect from parabens, the dosage would have to be 25,000 times that found in cosmetics.12

Mineral oil. The highly refined, pharmaceutical-grade of mineral oil has been an effective ingredient in skin care.13 It has been proven that it has no adverse effect on the stratum cornium.14, 15 Mineral oil has been shown to improve skin softness and is a safe ingredient that removes excess oil and can help dissolve comedones. Its value in treating oily skin is unquestioned. The claims that today’s pharmaceutical-grade mineral oil is carcinogenic are false with no data to support them.13, 15–17