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Resveratrol: A Real Anti-aging Product

By: Peter T. Pugliese, MD
Posted: November 25, 2008, from the December 2008 issue of Skin Inc. magazine.

page 7 of 13

So far, the evidence suggests that taking modest doses of resveratrol—from 100–200 mg—may help the body to metabolize fat better and activate the pathways that are turned on by CR. The other benefits of resveratrol make it worth taking as a supplement, even if the anti-aging aspect is not proven at this time.

Resveratol and NF-kB blockade

The esthetician should be familiar with this biological compound mentioned above. It is a transcription factor, so it activates some genes in the DNA molecule. This is a term that sooner or later you will need to know if you stay in the professional skin care field. Current evidence points out that by blocking the agents that turn on NF-κB, you will prevent the inflammatory action that is associated with aging and actually allow the body to reverse the aging changes.21 Now that is a profound statement because it describes a major biological discovery. This is not the whole story, by far. Two camps exist in science on the topic of anti-aging. One is the negative group, the naysayers who disagree with everything, and the other is the positive group who are making real strides in understanding the aging process, and at the same time are discovering the cause of many diseases and finding ways to treat them.

If you want to take resveratrol, it is important to read all the literature supplied by the vendor because it is a good source of information on resveratrol and to also speak with your physician. At present, with CR and resveratrol supplements, you have a good start on slowing down your aging rate.

Topical products will soon be available for skin care and should be very effective, but I strongly suggest you fully understand resveratrol and demand data for efficacy before you use or purchase these products.


a.Viniferins are complex molecules that develop in grape leaves and wood in response to fungal infections.