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Ingredient Review: The Safety of Paraben Substitutes

By Rebecca James Gadberry
Posted: March 26, 2008, from the April 2008 issue of Skin Inc. magazine.

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1.  R.E.D. FACTS: Methylisothiazolinone. EPA-738-F-98-008, Oct 1998
2.  Neolone data report, Rohm and Haas
3.  S Du, B McLaughlin, S Pal and E Aizenman, In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. J Neurosci, 22(17), 7408–7416 (Sept 1, 2002)
4.  K He, J Huang, CF Lagenaur and E Aizenman, Methylisothiazolinone, a neurotoxic biocide, disrupts the association of Src family tyrosine kinases with focal adhesion kinase in developing cortical neurons.
J Pharmacol Exp Therap, 317, 1320–1329 (2006)

Archived webinar:
Cutting-edge Ingredients 2008 by Rebecca James Gadberry (February 12, 2008)
Q & A from Cutting-edge Ingredients 2008 webinar with Rebecca James Gadberry (February 12, 2008)

Recent Ingredient Review columns:
Ingredient Review: The Truth About Chemicals, Mineral Oil, Squalene and Fillers by Rebecca James Gadberry (April 2007)

Recent news items regarding parabens and preservatives:
Study Reports Consumer Attachment to Naturals/Organics (January 22, 2008)
Growth for Naturals (September 24, 2007)