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Ingredient Review: The Safety of Paraben Substitutes
By Rebecca James Gadberry
Posted: March 26, 2008, from the April 2008 issue of Skin Inc. magazine.
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1. R.E.D. FACTS: Methylisothiazolinone. EPA-738-F-98-008, Oct 1998
2. Neolone data report, Rohm and Haas
3. S Du, B McLaughlin, S Pal and E Aizenman, In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. J Neurosci, 22(17), 7408–7416 (Sept 1, 2002)
4. K He, J Huang, CF Lagenaur and E Aizenman, Methylisothiazolinone, a neurotoxic biocide, disrupts the association of Src family tyrosine kinases with focal adhesion kinase in developing cortical neurons.
J Pharmacol Exp Therap, 317, 1320–1329 (2006)
Recent Ingredient Review columns:
Ingredient Review: The Truth About Chemicals, Mineral Oil, Squalene and Fillers by Rebecca James Gadberry (April 2007)
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Study Reports Consumer Attachment to Naturals/Organics (January 22, 2008)
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