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Skin and the Brain: Uncovering New Links

Claudia C. Aguirre and Annet King October 2012 issue of Skin Inc. magazine
male professional skin care client getting massage

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While scientific research during the past century has focused on identifying and studying separate somatic structures, functions and conditions, the newest discoveries spanning many disciplines uncover more about relationships between the body’s systems than the individual systems themselves. One area where this research is especially compelling is the ongoing dialogue between skin and the brain.

A reflection of the brain

In utero, both skin cells and brain cells develop from the same kind of embryonic tissue, called ectoderm. In the January 2012 issue of Proceedings of the National Academy of Sciences, researchers at the Stanford University School of Medicine in California conducting a study on mice were able to transform skin cells directly into brain cells, bypassing the stem cell stage, and further demonstrating this fundamental physiological link between skin and the brain.

Throughout life, the skin may be a reflection of changes within the brain, triggered by cascades of brain chemicals that have only recently started to be named and explored. For instance, the rise in adult acne may be linked to stress, which elevates both testosterone and cortisol levels. With natural aging, the decline of estrogen contributes to the loss of collagen and elastin, and the proliferation of hyperpigmentation—and these changes also affect the brain.

The role of oxytocin

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