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Dual Drug Therapy Effective Against Pemphigus Vulgaris

Posted: October 26, 2006

A new combination treatment offers hope to people who have the blistering, potentially fatal skin disease known as pemphigus vulgaris.

By combining the cancer-fighting drug rituximab with intravenous immune globulin, Harvard doctors have discovered a therapy that can effectively treat people with cases of pemphigus vulgaris that haven't responded to other treatments.

"We got a home run with this combination," said study co-author Dr. Marshall Posner, medical director of the head and neck oncology program at the Dana-Farber Cancer Institute and Harvard Medical School.

"These patients were extremely ill and on multiple medications," he said. "This therapy resulted in complete eradication of the disease for nine patients." The remaining two patients in the study required additional doses of the treatment before they, too, went into remission. All of those involved in the study had sustained remissions, some as long as 37 months, by the end of the study.

Results of the study are published in the Oct. 26 issue of the New England Journal of Medicine.