Sign in

Scientists Spot Psoriasis Gene

A variant of a single immune system gene boosts the risk for psoriasis, researchers report.

A team from the University of Michigan looked for the gene -- called PSORS1 -- in more than 2,700 people from 678 families in which at least one family member had psoriasis.

According to the researchers, PSORS1 is the first genetic determinant of psoriasis to be definitively identified in a large clinical trial. The finding may help in the development of new, more effective treatments for the disfiguring inflammatory skin disease.

To develop psoriasis, people must inherit several disease-related genes and also be exposed to one or more environmental triggers, such as a strep infection, the researchers noted.

"For every individual with psoriasis who carries the PSORS1 gene, there are 10 other people with the gene who don't get psoriasis," study director Dr. James T. Elder, a professor of dermatology and of radiation oncology, said in a prepared statement.

The PSORS1 gene is actually one of more than 20 different varieties of a gene called HLA-C, one of several genes that regulate how the immune system fights off infection.

While Elder and his colleagues have identified the PSORS1 gene -- which they believe is the major gene involved in psoriasis susceptibility -- they said that much more research is needed to identify other genes involved in the development of psoriasis.

The findings appear in the May issue of the American Journal of Human Genetics.

HealthDay News, March 22, 2006

Related Content

 

Skip

Welcome to the new SkinInc.com!

Delivering the best information on the spa, skin care and wellness industry is our passion, and we’ve worked hard to design a powerful new website that incorporates cutting-edge technology to bring you:

  • Mobile-friendly Design
  • Integrated Sample Request
  • Refreshed Look and Feel
  • Dynamic Content
  • Free Registration

Mobile-friendly Design

Providing a unified experience from mobile to desktop, responsive design allows you to access Skin Inc. content from any device, whether you’re in the treatment room, at home or on the go!

Integrated Sample Request

Visit Featured Product pages to quickly and easily identify new suppliers and request product samples and information.

Dynamic Content

Articles are now linked with relevant products so you can find the products and treatments you need to provide the best results for your clients.

Free Registration

Create your user account to gain unlimited access to Skin Inc.’s unparalleled content.

Enjoy the New SkinInc.com!

Thank you for joining the Skin Inc. community of passionate skin care professionals. We look forward to providing you the best information to enhance your career!