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Caffeine Lowers Risk of Skin Cancer: Coffee-based Sunscreen Might Work Best
Posted: August 31, 2011
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The study also found, however, that when both groups of mice were exposed to chronic ultraviolet rays for an extended period of time, tumor development occurred in both the genetically modified and regular mice. What this seems to indicate, says Conney, is that inhibiting the ATR enzyme works best at the pre-cancerous stage before UV-induced skin cancers are fully developed.
According to the National Cancer Institute, sunlight-induced skin cancer is the most prevalent cancer in the United States with more than 1 million new cases each year. Although multiple human epidemiologic studies link caffeinated beverage intake with significant decreases in several different types of cancer, including skin cancer, just how and why coffee protects against the disease is unknown.
"Caffeine might become a weapon in prevention because it inhibits ATR and also acts ad as a sunscreen and directly absorbs damaging UV light," said Conney.
1. M Kawasumi, B Lemos, JE Bradner, R Thibodeau, Y-S Kim, M Schmidt, E Higgins, S-W Koo, A Angle-Zahn, A Chen, D Levine, L Nguyen, TP Heffernan, I Longo, A Mandinova, Y-P Lu, AH Conney, and P Nghiem, Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1111378108 (Aug 15, 2011)
From ScienceDaily.com, August 25, 2011