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The more moles a person has, the more likely their DNA has properties that help slow aging, according to a U.K. study of 1,800 twins.
People with more than 100 moles had longer telomeres than people with fewer than 25 moles, the study found. Telomeres -- bundles of DNA found at the end of chromosomes in all cells -- help keep chromosome ends from fraying and sticking to one another, BBC News reported.
Telomeres shorten as people age. The difference in telomere length between study volunteers with more than 100 moles and those with fewer than 25 moles was equivalent to six to seven years of aging, said the study, which appears in the journal Cancer Epidemiology Biomarkers and Prevention.
"The results of this study are very exciting as they show, for the first time, that moley people who have a slightly increased risk of melanoma may, on the other hand, have the benefit of a reduce rate of aging," said lead researcher Dr. Veronique Bataille of King's College London, BBC News reported.
"This could imply susceptibility to fewer age-related diseases, such as heart disease or osteoporosis, for example. Further studies are needed to confirm these findings," Bataille said.
HealthDay News, July 12, 2007
More and more professional athletes are realizing how the dangerous effects from the sun can disrupt their game. From baseball to hockey, running to skiing, skin cancer is leaving its mark on athletes in a range of sports. To spread awareness and help strike out skin cancer, the most common form of cancer in the United States, the American Academy of Dermatology (AAD) is urging athletes to Be Sun Smart.
“Thousands of athletes, both professional and amateur, are at high risk for developing skin cancer,” warns dermatologist Brian B. Adams, MD, MPH, FAAD, and chairperson of the AAD’s Sports Committee. “Outdoor athletes face double jeopardy because perspiring exacerbates their risk.”
Perspiration on the skin lowers the minimal erythema dose, the lowest ultraviolet (UV) light exposure needed to turn the skin barely pink. "You've already set yourself up for trouble if you are not using sunscreen when outdoors participating in sports," commented Dr. Adams. "When you perspire, you are even more susceptible to a burn, and with continued exposure, to wrinkles, age spots and maybe even skin cancer.”
Skin cancer has left its mark on runner Deena Kastor, one of America's top distance runners and an Olympic bronze medalist in the marathon. "I have 25 external stitches for basal cell carcinoma and early stages of melanoma," said Kastor. “I also have six internal stitches to tie off blood vessels the doctor cut through because the cancer runs deep."
Kastor encourages the public to take the necessary steps to prevent skin cancer. “I can only emphasize that it is never one thing that causes skin cancer,” said Kastor. “Maintaining healthy skin is a combination of using sunscreen, wearing clothing and hats that cover you in the sun, limiting exposure to the midday sun, eating foods high in anti-oxidants and visiting the dermatologist regularly.”
The AAD recommends seeking shade from 10 a.m. to 4 p.m., which according to Dr. Adams is, "exactly the time when most teams are outside practicing, from soccer players to long-distance runners to tennis players. These athletes are getting an enormous amount of exposure to UV light and it’s important that they follow some sun-safety precautions, including wearing sunscreen and protective clothes.”
Skin cancer also occurs in athletes who do not compete in the sun. During training-camp physicals in 2002, National Hockey League player Mark Cullen's health took a negative turn. His doctor detected a suspicious mole under his arm and it was discovered to be melanoma, the most deadly form of skin cancer.
"It was a shock," Cullen said. "Anytime you hear the word 'cancer', especially feeling that I was a young, healthy person, I was shocked. It was a scary time in my life and while I'm glad to have gone through it, I'm glad to be healthy right now."
It took three separate surgeries to remove Cullen’s growth, surrounding lymph nodes, and some skin. Luckily, Cullen did not have to undergo chemotherapy or radiation, as he initially believed. Almost three years later and with regular six-month checkups, Cullen is cancer-free.
"The skin cancer diagnosis helped me prioritize my life in general," Cullen said, "and made me realize what was important to me -- to take a step back and look at your life and where you're headed right now because you never know how long you're going to get."
More than 1 million new cases of skin cancer are diagnosed each year and one American dies of melanoma almost every hour (every 65 minutes). Of these cases, more than 108,000 are melanoma, a cancer that claims nearly 8,000 lives annually.
Dermatologists encourage all athletes to Be Sun Smart since sun exposure is the most preventable risk factor for skin cancer. Here’s how to do it:
- Generously apply sunscreen to all exposed skin using a Sun Protection Factor (SPF) of at least 15 that provides broad-spectrum protection from both ultraviolet A (UVA) and ultraviolet B (UVB) rays. Re-apply every two hours, even on cloudy days, and after swimming or sweating. Look for the AAD SEAL OF RECOGNITIO on products that meet these criteria.
- Wear protective clothing, such as a long-sleeved shirt, pants, a wide-brimmed hat and sunglasses, where possible.
- Seek shade when appropriate, remembering that the sun’s rays are strongest between 10 a.m. and 4 p.m.
- Use extra caution near water, snow and sand as they reflect the damaging rays of the sun which can increase your chance of sunburn.
- Protect children from sun exposure by applying sunscreen.
- Get vitamin D safely through a healthy diet that includes vitamin supplements. Don’t seek the sun.
- Avoid tanning beds. Ultraviolet light from the sun and tanning beds can cause skin cancer and wrinkling. If you want to look like you’ve been in the sun, consider using a sunless self-tanning product, but continue to use sunscreen with it.
- Check your birthday suit on your birthday. If you notice anything changing, growing, or bleeding on your skin, see a dermatologist. Skin cancer is very treatable when caught early.
For more information about skin cancer or the AAD’s sun-safety sports programs, please visit www.aad.org.
Patients who used the psoriasis drug Enbrel for more than a year had no more adverse effects than patients taking a placebo, a new study found.
And most patients showed an improvement in their psoriasis, according to the study. Enbrel had previously been shown to be safe and effective when used over a short period of time, but the question remained whether long-term use of the drug would be safe.
"This drug is safe for long-term use," said lead author Dr. Stephen Tyring, a clinical professor of dermatology at the University of Texas Health Science Center at Houston. "During 96 weeks of follow-up, both the safety and efficacy of the drug were very good."
Enbrel (etanercept) is a drug that blocks tumor necrosis factor, a pro-inflammatory cytokine. People with an immune disease, such as psoriasis, have too much tumor necrosis factor (TNF) in their bodies. Enbrel reduces the amount of TNF to normal levels, but it can also lower the ability of the immune system to fight infections.
In the trial, Tyring's team randomly assigned 618 people with psoriasis to 12 weeks of treatment with Enbrel or a placebo. The patents received 50 milligrams of Enbrel twice a week. After the initial 12 weeks of treatment, 591 patients from both groups continued to receive Enbrel for 84 weeks.
The study researchers found that people receiving Enbrel or a placebo had a similar number of adverse reactions, including serious infections. "There was not a problem with increased infections or any other adverse events in using the drug for the long term, and this is at the higher dosage of 100 milligrams a week," Trying said.
What's more, by the end of the trial, the psoriasis had improved at least 75 percent for 51.1 percent of the original Enbrel group and 51.6 percent of the original placebo group.
The findings are published in the June issue of the Archives of Dermatology.
Tyring noted that Enbrel is not usually used alone, as it was in this trial, but in combination with other drugs, such as creams, as well as with light therapy. "So, in real life, we see better results," he said.
The main drawback to long-term Enbrel treatment is cost, Tyring said. "Like all five biological treatments for psoriasis, Enbrel is expensive, and if the patient doesn't have insurance, it is difficult to keep using this dosage and perhaps even a lower dosage," he said.
According to the National Psoriasis Foundation, Enbrel can cost $10,000 to $25,000 a year or more, depending on the dose and how often it is taken.
One skin disease expert agreed that long-term use of Enbrel is safe and effective, even at the higher dose.
"Physicians would love to use the drug this way," said Dr. Jeffrey M. Weinberg, director of the clinical research center in the department of dermatology at St. Luke's-Roosevelt Hospital Center, in New York City. "The limiting factor is cost," he added.
Some patients do well on 50 milligrams a week, Weinberg said. "But many people do better at the higher dose, especially those who weigh more," he said. "About 40 percent of patients would benefit from the higher dose."
By Steven Reinberg, HealthDay News, June 19, 2007
The University of Michigan Medical School recently reported that retinol reduces the fine lines and wrinkles associated with natural aging.
Overall exposure to the sun's ultraviolet (UV) rays in childhood, not just sunburns, may be a major factor influencing a person's risk for skin cancer later in life, suggest initial results of research looking at the interaction of genes and UV exposure in 214 people with melanoma, the most deadly form of skin cancer.
Dr. Nancy Thomas, a dermatologist at the University of North Carolina, used satellite data to track average UV radiation in the towns and states where the patients lived at different times of their lives, the Associated Press reported.
She and her colleagues found that the patients who'd experienced the highest UV exposure by age 20 had the highest number of melanoma-related BRAF gene mutations. The same patients also had the most moles, another important risk factor for melanoma.
More research is needed, but Thomas suggested that rapidly growing skin on young people may be especially vulnerable to damage from UV rays, the AP reported.
In related news, the U.S. Food and Drug Administration is putting the finishing touches to new rules for sunscreen ratings. Currently, sun protection factor (SPF) ratings tell consumers only how well a sunscreen protects against UV-B rays that cause sunburn.
The agency wants the SPF ratings to also include how well sunscreens protect against UV-A rays that cause cancer and wrinkles, the AP reported. The proposed changes should be introduced within the next few weeks, but are subject to a public comment period before they take effect.
HealthDay News, June 11, 2007
Melanoma patients with higher levels of a protein called S-100 in their blood may run a higher risk of having the potentially deadly skin cancer return, a new study says.
The study tested serum samples from 103 patients who were treated with high-dose interferon, a standard therapy for melanoma; the patients had been treated eight years earlier, on average. The disease recurred in 64 of the patients within an average of 30 months. When the researchers examined levels of S-100 in the serum samples, they found that the higher the level of the protein, the greater likelihood the patient's disease had returned.
"Melanoma patients who initially respond well to treatment with interferon are at high risk of their cancer recurring," said Dr. John Kirkwood, principal investigator of the study and a professor of medicine at the University of Pittsburgh School of Medicine and director of the school's Melanoma Center. "We know that only 30 percent of these patients benefit from treatment long-term. The goal of our study was to identify better predictors of who will benefit most from treatment with interferon and who is most at risk of their cancer returning."
The study also found that patients who survived longer showed increased evidence of an autoimmune response to treatment with interferon.
The study findings were to be presented Saturday at the annual meeting of the American Society of Clinical Oncology, in Chicago.
"With further study, we hope to learn more about the role of S-100 in melanoma survival," said Joseph Stuckert, a medical student at the University of Pittsburgh School of Medicine who was to present the study at the meeting. "S-100 may be an important key to better stratifying patients into those more or less likely to relapse."
The next step in the research, Stuckert said, is to identify factors that may make patients more likely to develop autoimmunity and to further examine the role of S-100 as a potential biomarker for melanoma.
Malignant melanoma is one of the deadliest forms of skin cancer. Nearly 60,000 new cases of melanoma are expected in 2007, and 8,100 deaths are expected to occur.
The study was funded by a grant from the U.S. National Cancer Institute.
HealthDay News, June 2, 2007
By Diana L. Howard, PhD
Teach your clients about the three biochemical reactions that cause aging skin.
By Tracy Sherwood
Wrinkle reducers aren’t the only thing consumers are looking for in skin care products anymore.
U.S. researchers say they've spotted a key immune system dysfunction in patients with melanoma skin cancer.
A team at Stanford University School of Medicine, in California, found that the immune cells in most melanoma patients fail to respond properly to a molecule called interferon, which normally activates the immune system. This failure to respond to interferon means that the immune cells don't fight off melanoma.
The findings, published in the May issue of the journal Public Library of Science-Medicine, could help in the development of new treatments for melanoma.
Melanoma will kill about 16 percent of the 47,700 people in the United States expected to be diagnosed with this form of skin cancer this year.
These findings help explain why a common melanoma treatment involving prolonged exposure to interferon sometimes helps melanoma patients, said senior author Dr. Peter Lee, associate professor of medicine.
"Doctors knew it worked in some people but didn't know why," Lee said in a prepared statement. This study suggests that prolonged interferon treatment may work by overcoming the immune system's inability to respond to interferon.
Previous research has found that cancer patients often have immune system problems, but, until now, scientists didn't know which genes or pathways were at the root of the trouble. Identification of this interferon response disruption may boost efforts to develop vaccines for different types of cancer, the Stanford researchers said.
"We think this is a dominant way that immune dysfunction occurs in people with cancer," Lee said
HealthDay News, May 14, 2007
People who unwind with a cup of tea every night may have a lower risk of two common forms of skin cancer, new research suggests.
In a study of nearly 2,200 adults, researchers found that tea drinkers had a lower risk of developing squamous cell or basal cell carcinoma, the two most common forms of skin cancer.
Men and women who had ever been regular tea drinkers -- having one or more cups a day -- were 20 percent to 30 percent less likely to develop the cancers than those who didn't drink tea.
The effect was even stronger among study participants who'd been tea fans for decades, as well as those who regularly had at least two cups a day, according to findings published in the Journal of the American Academy of Dermatology.
However, the findings do not mean it's okay to bake in the sun as long as you have a cup of tea afterward. The researchers found no evidence that tea drinking lowered skin cancer risk in people who'd accumulated painful sunburns in the past.
Nor did the study look at the relationship between tea drinking and malignant melanoma, the least common but most deadly form of skin cancer.
Still, the findings support the theory that tea antioxidants may limit the damage UV radiation inflicts on the skin, according to the study authors, led by Dr. Judy R. Rees of Dartmouth Medical School in Lebanon, New Hampshire.
In particular, a tea antioxidant known as EGCG has been shown to reduce burning on UV-exposed skin.
The current findings are based on interviews with 770 New Hampshire residents with basal cell carcinoma, 696 with squamous cell carcinoma, and 715 cancer-free men and women the same age.
Tea consumption was linked to a lower skin cancer risk, even with factors such as age, skin type and history of severe burns considered. However, tea drinkers who'd suffered multiple painful burns in the past did not have a lower risk of skin cancer.
It's possible, the researchers explain, that the antioxidants in tea are enough to limit skin damage caused by moderate sun exposure, but not the "more extreme" effects of sun exposure, such as cancer-promoting damage to the DNA in skin cells.
SOURCE: Journal of the American Academy of Dermatology, May 2007.
HealthDay News, May 4, 2007